This search combines search strings from the content search (i.e. "Full Text", "Author", "Title", "Abstract", or "Keywords") with "Article Type" and "Publication Date Range" using the AND operator.
Beilstein J. Org. Chem. 2019, 15, 96–105, doi:10.3762/bjoc.15.11
Graphical Abstract
Figure 1: Tubulysin A (1) and tubugi-1 (2).
Scheme 1: Retrosynthetic analysis of the modular attachment linker tubugi-1-SSPy (3).
Scheme 2: Synthesis of tubugi-1-SSPy (3): a) LiOH·H2O, THF/H2O, 0 °C → rt; b) Ac2O, py; c) 4, HBTU, DMF, DIPE...
Scheme 3: Synthesis of the tubugi-1–NPY conjugate [K4(C(tubugi-1)-βA-),F7,L17,P34]-hNPY (8).
Scheme 4: Toxin liberation by disulfide linker cleavage from the activated toxin conjugate under reductive co...
Figure 2: Reduction of viability and proliferation of SK-N-MC, MDA-MB-468, MDA-MB-231 cancer cell lines, and ...